Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047866 | 0.93 | CYP11B1 (0.36) | GRM4CYP11B1CYP11B2CDC7DBF4 | |
| SCHEMBL1051493 | 0.92 | GRM4 (0.42) | GRM4KCNH2CDC7DBF4KDM4E | |
| SCHEMBL1000214 | 0.80 | GRM4 (0.45) | GRM4KCNH2KDM4EILK | |
| SCHEMBL366105 | 0.70 | GRM4 (0.70) | GRM4KCNH2 | |
| SCHEMBL1051726 | 0.67 | CYP11B1 (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL1049256 | 0.66 | GRM4 (0.57) | GRM4KCNH2KDM4EILK | |
| SCHEMBL13306656 | 0.61 | GRM4 (0.41) | GRM4CDC7DBF4KDM4EILK | |
| SCHEMBL15049877 | 0.61 | GRM4 (0.48) | GRM4KCNH2KDM4EILK | |
| SCHEMBL3288656 | 0.60 | CNR2 (0.47) | GRM4KCNH2 | |
| SCHEMBL22783773 | 0.59 | PIK3CD (0.43) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456769-B1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2013-06-26 | — | — | EP | claimed |