Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.67 |
| ▸ | KDR | P35968 | 17/20 | 0.67 |
| ▸ | AURKA | O14965 | 8/20 | 0.61 |
| ▸ | TEK | Q02763 | 8/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.61 |
| ▸ | FLT4 | P35916 | 5/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189126 | 0.94 | EGFR (0.70) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL1504819 | 0.92 | EGFR (0.79) | EGFRKDRAURKATEKPDGFRB | |
| Acetic Acid SCHEMBL1504854 | 0.92 | EGFR (0.68) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL1505033 | 0.90 | EGFR (0.62) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL1504964 | 0.90 | EGFR (0.62) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL1505042 | 0.90 | EGFR (0.64) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL1504846 | 0.89 | EGFR (0.67) | EGFRKDRAURKATEKPDGFRB | |
| 4Sc-203 SCHEMBL1505017 | 0.89 | EGFR (0.64) | EGFRKDRAURKATEKPDGFRB | |
| 4Sc-203 SCHEMBL29370845 | 0.89 | EGFR (0.64) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL3946261 | 0.88 | EGFR (0.70) | EGFRKDRAURKATEKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033094-A1 | SCHEDULE OF ADMINISTRATION OF BENZAZOLE DERIVATIVES IN THE TREATMENT OF LEUKEMIAS | 4SC AG (DE) | 2011-03-24 | — | — | WO | claimed |
| WO-2011033094-A1 | SCHEDULE OF ADMINISTRATION OF BENZAZOLE DERIVATIVES IN THE TREATMENT OF LEUKEMIAS | 4SC AG (DE) | 2011-03-24 | — | — | WO | disclosed |