Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 8/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.31 |
| ▸ | TUBB | P07437 | 3/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.31 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511974 | 1.00 | MAPK1 (0.34) | MAPK1CHRM3ABL1CHRM2CHRM1 | |
| SCHEMBL31511973 | 0.92 | MAPK1 (0.38) | MAPK1CHRM3ABL1TUBB4ATUBB | |
| SCHEMBL15051226 | 0.92 | MAPK1 (0.38) | MAPK1CHRM3ABL1TUBB4ATUBB | |
| SCHEMBL15072397 | 0.89 | MAPK1 (0.37) | MAPK1ABL1TUBB4ATUBBTUBA3C | |
| SCHEMBL15050758 | 0.86 | PIK3C3 (0.37) | MAPK1ABL1TUBB4ATUBBTUBA3C | |
| SCHEMBL15051721 | 0.86 | ABL1 (0.38) | MAPK1ABL1 | |
| SCHEMBL15050933 | 0.85 | MAPK8 (0.37) | MAPK1ABL1TUBB4ATUBBTUBA3C | |
| SCHEMBL15072470 | 0.84 | JAK2 (0.37) | CHRM3ABL1TUBB4ATUBBTUBA3C | |
| SCHEMBL31511978 | 0.84 | JAK2 (0.37) | CHRM3ABL1TUBB4ATUBBTUBA3C | |
| SCHEMBL15051329 | 0.84 | NPC1 (0.40) | MAPK1ABL1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | MAPK1 1590/4885CHRM3 3973/4885ABL1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.