Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18198334 | 0.91 | HSD17B10 (0.39) | EPHX2USP2SMN1; SMN2HSD17B10KDM1A | |
| SCHEMBL18198354 | 0.86 | HSD17B10 (0.37) | USP2SMN1; SMN2HSD17B10CHRM2CHRM1 | |
| SCHEMBL16224360 | 0.84 | CHRM2 (0.36) | EPHX2ACACBUSP2SMN1; SMN2HSD17B10 | |
| SCHEMBL10281624 | 0.84 | CHRM2 (0.36) | EPHX2ACACBUSP2SMN1; SMN2HSD17B10 | |
| SCHEMBL16994160 | 0.84 | CHRM2 (0.36) | EPHX2ACACBUSP2SMN1; SMN2HSD17B10 | |
| SCHEMBL31449817 | 0.84 | JAK2 (0.37) | EPHX2JAK2JAK1ACACBUSP2 | |
| SCHEMBL31449921 | 0.84 | JAK2 (0.37) | EPHX2JAK2JAK1ACACBUSP2 | |
| SCHEMBL26151530 | 0.83 | EPHX2 (0.36) | EPHX2USP2SMN1; SMN2HSD17B10KDM1A | |
| SCHEMBL19389951 | 0.83 | EPHX2 (0.38) | EPHX2JAK2JAK1ACACBUSP2 | |
| SCHEMBL26544362 | 0.83 | EPHX2 (0.38) | EPHX2JAK2JAK1ACACBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102573-A1 | SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS | AXXAM S.p.A. (IT) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015118019-A9 | SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS | AXXAM S.P.A. (IT) | 2016-04-21 | — | — | WO | disclosed |
| WO-2015118019-A1 | SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS | AXXAM S.P.A. (IT) | 2015-08-13 | — | — | WO | disclosed |
| WO-2013095275-A1 | NOVEL HEPATITIS C VIRUS INHIBITORS | MEDIVIR AB (SE) | 2013-06-27 | — | — | WO | disclosed |