Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 10/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | TCF4 | P15884 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056048 | 0.94 | PFKFB3 (0.75) | PFKFB3PFKFB4POLBPLAUPLAT | |
| SCHEMBL15056062 | 0.93 | PFKFB3 (0.75) | PFKFB3HSD17B10HPGDACLYPFKFB4 | |
| SCHEMBL9997247 | 0.91 | PFKFB3 (1.00) | PFKFB3HSD17B10HPGDACLYMCL1 | |
| SCHEMBL9997882 | 0.91 | PFKFB3 (0.77) | PFKFB3HSD17B10HPGDACLYMCL1 | |
| SCHEMBL15055734 | 0.89 | PFKFB3 (0.70) | PFKFB3PFKFB4ALDH1A1POLBPLAU | |
| SCHEMBL15056332 | 0.88 | PFKFB3 (0.74) | PFKFB3HSD17B10HPGDACLYMCL1 | |
| SCHEMBL15055350 | 0.88 | PFKFB3 (0.87) | PFKFB3PFKFB4POLBPLAUPLAT | |
| SCHEMBL15055211 | 0.86 | PFKFB3 (0.67) | PFKFB3PFKFB4 | |
| SCHEMBL9997109 | 0.86 | PFKFB3 (0.71) | PFKFB3HSD17B10HPGDACLYMCL1 | |
| SCHEMBL9996967 | 0.86 | PFKFB3 (0.71) | PFKFB3HSD17B10HPGDACLYMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794009-B1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2017-08-30 | — | — | EP | claimed |
| EP-2794009-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | Kancera AB (SE) | 2014-10-29 | — | — | EP | claimed |
| WO-2013093095-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2013-06-27 | — | — | WO | claimed |