Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 13/20 | 0.43 |
| ▸ | PAK3 | O75914 | 8/20 | 0.43 |
| ▸ | PAK2 | Q13177 | 8/20 | 0.43 |
| ▸ | PAK4 | O96013 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071193 | 0.80 | PAK1 (0.61) | PAK1PAK3PAK2PAK4AURKA | |
| SCHEMBL15071199 | 0.79 | PAK1 (0.66) | PAK1PAK3PAK2PAK4IGF1R | |
| SCHEMBL15059363 | 0.71 | MKNK1 (0.41) | PAK1PAK4IGF1R | |
| SCHEMBL15217685 | 0.70 | PAK1 (0.62) | PAK1PAK3PAK2PAK4AURKA | |
| SCHEMBL15058540 | 0.68 | IGF1R (0.40) | PAK1PAK3PAK2PAK4AURKA | |
| SCHEMBL15217675 | 0.67 | PAK1 (0.67) | PAK1PAK3PAK2PAK4IGF1R | |
| SCHEMBL15059118 | 0.67 | IGF1R (0.50) | IGF1R | |
| SCHEMBL15216590 | 0.66 | PAK1 (0.54) | PAK1PAK3PAK2PAK4AURKA | |
| SCHEMBL15208646 | 0.66 | PAK1 (0.65) | PAK1PAK3PAK2PAK4IGF1R | |
| SCHEMBL15217673 | 0.65 | PAK1 (0.68) | PAK1PAK3PAK2PAK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794605-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092940-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |