Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.62 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15073558 | 0.89 | RPS6KB1 (0.62) | RPS6KB1AKT1 | |
| SCHEMBL15054259 | 0.85 | RPS6KB1 (0.66) | RPS6KB1AKT1 | |
| SCHEMBL15073592 | 0.76 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15054555 | 0.75 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15054930 | 0.73 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL18192371 | 0.73 | RPS6KB1 (0.80) | RPS6KB1AKT1 | |
| SCHEMBL15055219 | 0.71 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15053859 | 0.71 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15053862 | 0.71 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15060296 | 0.71 | RPS6KB1 (1.00) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794571-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096194-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |