Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 14/20 | 0.70 |
| ▸ | PAK4 | O96013 | 1/20 | 0.70 |
| ▸ | PAK3 | O75914 | 12/20 | 0.68 |
| ▸ | PAK2 | Q13177 | 12/20 | 0.68 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071169 | 0.82 | PAK1 (1.00) | PAK1PAK4PAK3PAK2PKN1 | |
| SCHEMBL15059329 | 0.81 | PAK1 (1.00) | PAK1PAK4PAK3PAK2PKN1 | |
| SCHEMBL15060160 | 0.81 | PAK1 (1.00) | PAK1PAK4PAK3PAK2PKN1 | |
| SCHEMBL15216467 | 0.78 | PAK1 (0.58) | PAK1PAK4PAK3PAK2 | |
| SCHEMBL15209021 | 0.75 | PAK1 (0.82) | PAK1PAK4PAK3PAK2 | |
| SCHEMBL15216470 | 0.74 | PAK1 (0.70) | PAK1PAK4PAK3PAK2PKN1 | |
| SCHEMBL15071040 | 0.71 | PAK1 (1.00) | PAK1PAK4PAK3PAK2 | |
| SCHEMBL15071068 | 0.71 | PKN1 (0.79) | PAK1PAK4PAK3PAK2PKN1 | |
| SCHEMBL15071039 | 0.71 | PAK1 (1.00) | PAK1PAK4PAK3PAK2 | |
| SCHEMBL14723359 | 0.71 | PAK1 (0.54) | PAK1PAK4PAK3PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794605-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | claimed |
| WO-2013092940-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | claimed |