Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 8/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | PAK3 | O75914 | 5/20 | 0.40 |
| ▸ | PAK2 | Q13177 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15091646 | 0.91 | PKN1 (0.51) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15060349 | 0.84 | PAK1 (0.40) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15057970 | 0.81 | PAK1 (0.39) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15091410 | 0.80 | PAK1 (0.63) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15091882 | 0.80 | PAK1 (0.63) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15059672 | 0.80 | PAK1 (0.61) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15208496 | 0.77 | IGF1R (0.43) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15058540 | 0.77 | IGF1R (0.40) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15209494 | 0.73 | PAK1 (0.53) | PKN1PAK1PAK4PAK3PAK2 | |
| SCHEMBL15059617 | 0.72 | PAK1 (0.62) | PAK1PAK4PAK3PAK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794605-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | claimed |
| WO-2013092940-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | claimed |