Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15020844 | 0.89 | HTR2C (0.34) | KITCLK2CLK3DYRK1A | |
| SCHEMBL15021244 | 0.84 | ORAI1 (0.41) | ORAI1CLK2CLK3DYRK1APTGS2 | |
| SCHEMBL15020834 | 0.82 | PIK3C3 (0.35) | KITORAI1 | |
| SCHEMBL15036344 | 0.80 | CLK2 (0.38) | KITCLK2CLK3DYRK1A | |
| SCHEMBL12745918 | 0.77 | CLK2 (0.39) | CLK2CLK3DYRK1A | |
| SCHEMBL15020511 | 0.77 | ORAI1 (0.41) | KITORAI1CLK2DYRK1APTGS2 | |
| SCHEMBL15020532 | 0.76 | CYP17A1 (0.45) | KITORAI1PTGS2 | |
| SCHEMBL15020476 | 0.76 | BRD4 (0.43) | KIT | |
| SCHEMBL15020878 | 0.73 | CYP19A1 (0.40) | KITCLK2CLK3DYRK1A | |
| SCHEMBL1460211 | 0.71 | CLK2 (0.47) | KITCLK2CLK3DYRK1APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013092467-A1 | 7-AZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | claimed |