Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14670353 | 0.81 | CYP3A4 (0.32) | GRM5BACE1CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL3023334 | 0.80 | NR3C2 (0.38) | BACE1 | |
| SCHEMBL13431070 | 0.76 | BACE1 (0.31) | BACE1 | |
| SCHEMBL15062302 | 0.75 | GRM5 (0.34) | GRM5BACE1CYP1A2 | |
| SCHEMBL3025613 | 0.74 | MAPT (0.38) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL12085058 | 0.70 | BACE1 (0.34) | GRM5BACE1 | |
| SCHEMBL15062301 | 0.70 | — | — | |
| SCHEMBL14670455 | 0.70 | BACE1 (0.35) | GRM5BACE1 | |
| SCHEMBL3017342 | 0.69 | KDM4E (0.39) | MEN1KMT2ACYP3A4CYP2C19KDM4E | |
| SCHEMBL3011515 | 0.69 | NR3C2 (0.46) | BACE1CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2179994-B1 | FUSED BICYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-06-26 | — | — | EP | disclosed |