Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506253 | 1.00 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL1498047 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL2831685 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL5140053 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL1498096 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL4892041 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL1498072 | 0.86 | HRH3 (0.40) | HRH3KCNH2QPCTQPCTLHSD11B1 | |
| SCHEMBL1506290 | 0.86 | HRH3 (0.46) | HRH3KCNH2HTR3A | |
| SCHEMBL1506288 | 0.86 | HRH3 (0.46) | HRH3KCNH2HTR3A | |
| SCHEMBL1506228 | 0.83 | HRH3 (0.51) | HRH3KCNH2QPCTQPCTLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298734-A2 | Cyclobutyl amine derivatives | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | claimed |
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-09-10 | — | — | US | claimed |
| US-7553964-B2 | Cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-06-30 | — | — | US | claimed |
| US-20070078133-A1 | Cyclobutyl amine derivatives | ABBVIE INC. | 2007-04-05 | — | — | US | claimed |
| EP-2298734-A2 | Cyclobutyl amine derivatives | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-09-10 | — | — | US | disclosed |
| US-7553964-B2 | Cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070078133-A1 | Cyclobutyl amine derivatives | ABBVIE INC. | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885KCNH2 1616/4885QPCT 876/4885 |
| US-20070078133-A1 | Cyclobutyl amine derivatives | HRH2, HRH4, HRH3 | HRH3 3/4885KCNH2 1616/4885QPCT 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.