Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 8/20 | 0.81 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3356228 | 1.00 | CSNK1E (0.81) | CSNK1EIRAK4PIM1AKT1CHRNB2 | |
| SCHEMBL3115771 | 0.90 | CSNK1E (1.00) | CSNK1EAKT1 | |
| SCHEMBL3105680 | 0.84 | CSNK1E (0.75) | CSNK1EPIM1AKT1 | |
| SCHEMBL3105686 | 0.84 | CSNK1E (0.75) | CSNK1EPIM1AKT1 | |
| SCHEMBL17976949 | 0.83 | CSNK1E (0.74) | CSNK1EPIM1 | |
| SCHEMBL3121793 | 0.83 | CSNK1E (0.74) | CSNK1EPIM1AKT1CHRNB2CHRNA4 | |
| SCHEMBL17976950 | 0.83 | CSNK1E (0.74) | CSNK1EPIM1 | |
| SCHEMBL3116426 | 0.82 | CSNK1E (1.00) | CSNK1E | |
| SCHEMBL3116432 | 0.82 | CSNK1E (1.00) | CSNK1E | |
| SCHEMBL3356262 | 0.80 | CSNK1E (0.54) | CSNK1EAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178879-B1 | 6-CYCLOAMINO-S-(PYRIDAZIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE AND DERIVATIVES THEREOF PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2013-07-03 | — | — | EP | claimed |