Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.85 |
| ▸ | JAK3 | P52333 | 20/20 | 0.85 |
| ▸ | JAK1 | P23458 | 19/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062896 | 1.00 | JAK2 (0.85) | JAK2JAK3JAK1 | |
| SCHEMBL11962858 | 0.94 | JAK2 (0.84) | JAK2JAK3JAK1 | |
| SCHEMBL11962859 | 0.94 | JAK2 (0.84) | JAK2JAK3JAK1 | |
| SCHEMBL12546139 | 0.92 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1948684 | 0.89 | JAK2 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL1948685 | 0.89 | JAK2 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL1555595 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1555208 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1949668 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL15062958 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633206-B2 | Pyrrolo[2,3-D]pyrimidine compounds | PFIZER INC. (US) | 2014-01-21 | — | — | US | disclosed |
| EP-2488524-B1 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | PFIZER (US) | 2013-07-03 | — | — | EP | disclosed |