Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 12/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506401 | 0.85 | MEN1 (0.56) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL4251022 | 0.82 | MAPT (0.65) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL27575330 | 0.81 | RAF1 (0.54) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL4238737 | 0.80 | RAF1 (0.67) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL4244650 | 0.80 | RAF1 (0.63) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL14217230 | 0.77 | RAF1 (0.58) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL617631 | 0.77 | RAF1 (0.65) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL178167 | 0.77 | RAF1 (0.64) | MAPTRAF1BRAFMEN1KMT2A | |
| SCHEMBL1506305 | 0.75 | RAF1 (0.84) | MAPTLMNAHSP90AA1HTTRECQL | |
| SCHEMBL938321 | 0.72 | RAF1 (0.74) | MAPTRAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158985-A4 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2008-03-12 | — | — | EP | claimed |
| JP-3845792-B2 | — | — | 2006-11-15 | — | — | JP | claimed |
| EP-1690853-A1 | W-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | Bayer Pharmaceuticals Corporation (US) | 2006-08-16 | — | — | EP | claimed |
| US-20030207872-A1 | OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BAYER CORPORATION | 2003-11-06 | — | — | US | claimed |
| US-20030181442-A1 | Carbamides such as N-(3-tert-butylphenyl)-N'-(4-(3-(N-methyl-carbamoyl)phenoxy)phenyl urea, used as enzyme inhibitors and as anticarcinogenic agents | BAYER CORPORATION | 2003-09-25 | — | — | US | claimed |
| JP-2003526613-A | — | — | 2003-09-09 | — | — | JP | claimed |
| US-20030144278-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER CORPORATION | 2003-07-31 | — | — | US | claimed |
| US-20030105091-A1 | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC | 2003-06-05 | — | — | US | claimed |
| JP-2002534468-A | — | — | 2002-10-15 | — | — | JP | claimed |
| US-20020137774-A1 | Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER CORPORATION | 2002-09-26 | — | — | US | claimed |
| US-20020042517-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER CORPORATION | 2002-04-11 | — | — | US | claimed |
| EP-1158985-A1 | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | Bayer Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| US-20010034447-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC | 2001-10-25 | — | — | US | claimed |
| EP-1140840-A1 | -G(V)-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | Bayer Corporation (US) | 2001-10-10 | — | — | EP | claimed |
| US-20010027202-A1 | Omega-carboxyaryl substituted disphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC | 2001-10-04 | — | — | US | claimed |
| US-20010016659-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC | 2001-08-23 | — | — | US | claimed |
| US-20010011135-A1 | Omega-carboxyaryl subsituted diphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC | 2001-08-02 | — | — | US | claimed |
| US-20010011136-A1 | omega-carboxyyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER HEALTHCARE LLC | 2001-08-02 | — | — | US | claimed |
| WO-2000041698-A1 | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | claimed |
| WO-2000042012-A1 | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181442-A1 | Carbamides such as N-(3-tert-butylphenyl)-N'-(4-(3-(N-methyl-carbamoyl)phenoxy)phenyl urea, used as enzyme inhibitors and as anticarcinogenic agents | NRAS, BRAF, RAF1 | MAPT 1252/4885LMNA 2494/4885HSP90AA1 1689/4885 |
| US-20010011135-A1 | Omega-carboxyaryl subsituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, ARAF | MAPT 2180/4885LMNA 2915/4885HSP90AA1 2108/4885 |
| US-20010011136-A1 | omega-carboxyyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, ARAF, RAF1 | MAPT 2754/4885LMNA 3163/4885HSP90AA1 2373/4885 |
| US-20020137774-A1 | Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, NRAS | MAPT 1368/4885LMNA 4084/4885HSP90AA1 1761/4885 |
| US-20010034447-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, ARAF | MAPT 2299/4885LMNA 3199/4885HSP90AA1 2130/4885 |
| US-20010016659-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, ARAF | MAPT 2299/4885LMNA 3199/4885HSP90AA1 2130/4885 |
| US-20030207872-A1 | OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | MAPT 2299/4885LMNA 3199/4885HSP90AA1 2130/4885 |
| US-20030144278-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, ARAF | MAPT 2299/4885LMNA 3199/4885HSP90AA1 2130/4885 |
| US-20030105091-A1 | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | MAPK1, MAPK8, MAPK3 | MAPT 1103/4885LMNA 2805/4885HSP90AA1 1319/4885 |
| US-20010027202-A1 | Omega-carboxyaryl substituted disphenyl ureas as raf kinase inhibitors | BRAF, NRAS, ARAF | MAPT 2928/4885LMNA 3574/4885HSP90AA1 2392/4885 |
| US-20020042517-A1 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BRAF, RAF1, ARAF | MAPT 2299/4885LMNA 3199/4885HSP90AA1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.