Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | AKT2 | P31751 | 8/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323332 | 0.90 | HTR2C (0.69) | JAK3HTR2CAKT2GSK3BJAK2 | |
| SCHEMBL322769 | 0.88 | JAK3 (0.72) | JAK3HTR2CAKT2GSK3BKIT | |
| SCHEMBL28379761 | 0.85 | JAK3 (0.61) | JAK3HTR2CAKT2GSK3BJAK2 | |
| SCHEMBL1048666 | 0.83 | JAK3 (0.80) | JAK3HTR2CAKT2GSK3BJAK2 | |
| SCHEMBL24491026 | 0.81 | JAK3 (0.88) | JAK3HTR2CAKT2GSK3BKIT | |
| SCHEMBL24804166 | 0.80 | HTR2C (0.67) | JAK3HTR2CAKT2GSK3BJAK2 | |
| SCHEMBL1047971 | 0.79 | JAK3 (0.84) | JAK3HTR2CAKT2GSK3BKIT | |
| SCHEMBL10207321 | 0.78 | JAK3 (1.00) | JAK3HTR2CAKT2GSK3BKIT | |
| SCHEMBL10206809 | 0.77 | JAK3 (0.93) | JAK3HTR2CAKT2GSK3BKIT | |
| SCHEMBL19011824 | 0.77 | JAK3 (0.93) | JAK3HTR2CAKT2GSK3BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586961-B2 | Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2017-03-07 | — | — | US | disclosed |
| US-20130172325-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172325-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | JAK1, JAK2, JAK3 | JAK3 3/4885HTR2C 689/4885AKT2 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.