Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 16/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167978 | 0.88 | PRKDC (0.80) | PRKDCATMKIT | |
| SCHEMBL257303 | 0.88 | PRKDC (0.54) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL257190 | 0.88 | PRKDC (0.66) | PRKDCATMKIT | |
| SCHEMBL10060788 | 0.87 | PRKDC (0.57) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15082541 | 0.85 | PRKDC (0.57) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL16488198 | 0.80 | PRKDC (0.54) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL10060787 | 0.80 | PRKDC (0.56) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15006658 | 0.77 | PRKDC (0.74) | PRKDC | |
| SCHEMBL167275 | 0.77 | PRKDC (1.00) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL256573 | 0.77 | PRKDC (0.74) | PRKDCATMKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | PRKDC 170/4885ATM 7/4885PIK3CD 416/4885 |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | CHEK1, CHEK2, TTK | PRKDC 170/4885ATM 7/4885PIK3CD 416/4885 |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | PRKDC 170/4885ATM 7/4885PIK3CD 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.