Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16674796 | 0.88 | SLC16A3 (0.56) | SLC16A3MAPTALDH1A1APPKDM4E | |
| SCHEMBL15066750 | 0.86 | MAOB (0.49) | SLC16A3MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL15086510 | 0.86 | MAOB (0.49) | SLC16A3MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL28868213 | 0.83 | SLC16A3 (0.52) | SLC16A3MAPTALDH1A1APPKDM4E | |
| SCHEMBL15065820 | 0.79 | SLC16A3 (0.57) | SLC16A3MAPTALDH1A1APPKDM4E | |
| SCHEMBL16669729 | 0.79 | SLC16A3 (0.57) | SLC16A3MAPTALDH1A1APPKDM4E | |
| SCHEMBL4505056 | 0.76 | SLC16A3 (0.75) | SLC16A3MAPTALDH1A1APPKDM4E | |
| SCHEMBL18493220 | 0.74 | SLC16A3 (0.81) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15138692 | 0.74 | SLC16A3 (0.81) | SLC16A3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16312889 | 0.73 | SLC16A3 (0.70) | SLC16A3MAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |