Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084471 | 0.87 | HDAC11 (0.39) | PARP1HDAC11TNKS2PARP2KDM4E | |
| SCHEMBL17715018 | 0.82 | PARP1 (0.50) | PARP1PBRM1GFERSMN1; SMN2KDM4E | |
| SCHEMBL15069471 | 0.79 | GFER (0.52) | PARP1PBRM1GFERSMN1; SMN2TNKS2 | |
| SCHEMBL18687016 | 0.76 | PARP1 (0.39) | PARP1TNKS2PARP2HSD17B10 | |
| SCHEMBL2485381 | 0.72 | GFER (0.60) | PARP1PBRM1GFERSMN1; SMN2TNKS2 | |
| SCHEMBL17715014 | 0.69 | KDM4E (0.43) | PARP1KDM4EALDH1A1 | |
| SCHEMBL31510880 | 0.68 | HTR2A (0.51) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31510878 | 0.68 | HTR2A (0.51) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4026240 | 0.68 | KMT2A (0.58) | PARP1SMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL15067435 | 0.68 | KDM4E (0.52) | GFERSMN1; SMN2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| EP-2797919-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BeiGene, Ltd. (KY) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |