Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.46 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12170929 | 0.89 | MYC (0.56) | MYCNPC1RAB9ANR1H4KMT2A | |
| SCHEMBL12172012 | 0.88 | NR1H4 (0.67) | MYCNPC1RAB9ANR1H4KMT2A | |
| SCHEMBL12796834 | 0.86 | NPC1 (0.60) | MYCNPC1RAB9ANR1H4KMT2A | |
| SCHEMBL12171419 | 0.85 | MYC (0.64) | MYCNPC1RAB9ANR1H4KMO | |
| SCHEMBL12171364 | 0.85 | NPC1 (0.73) | MYCNPC1RAB9AKMOKMT2A | |
| SCHEMBL1505181 | 0.83 | NPC1 (0.66) | MYCNPC1RAB9AKMOKMT2A | |
| SCHEMBL4395868 | 0.82 | NPC1 (0.72) | MYCNPC1RAB9AKMOKMT2A | |
| SCHEMBL11579267 | 0.82 | NPC1 (0.66) | MYCNPC1RAB9AKMOKMT2A | |
| SCHEMBL12171432 | 0.82 | MYC (0.60) | MYCNPC1RAB9ANR1H4KMT2A | |
| SCHEMBL12171357 | 0.82 | NR1H4 (0.58) | MYCNPC1RAB9ANR1H4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311455-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| EP-2301538-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |