Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15086320 | 0.93 | NPC1 (0.46) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL16669511 | 0.89 | MAPT (0.38) | GHSRMIF | |
| SCHEMBL15066310 | 0.86 | NPC1 (0.46) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL15066761 | 0.85 | NPC1 (0.56) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL15067015 | 0.85 | NPC1 (0.56) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL21301370 | 0.84 | NPC1 (0.47) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL21301361 | 0.84 | NPC1 (0.47) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL15066182 | 0.84 | NPC1 (0.47) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL15066805 | 0.82 | NPC1 (0.47) | GHSRNPC1TLR9ATMTDP1 | |
| SCHEMBL15066145 | 0.82 | NPC1 (0.50) | NPC1TLR9ATMTDP1ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |