Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646508 | 0.84 | SRC (0.61) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5352369 | 0.73 | BRAF (0.61) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL1647214 | 0.73 | KDR (0.72) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5698604 | 0.72 | CSNK1D (1.00) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5257540 | 0.72 | CSNK1D (1.00) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5354206 | 0.71 | BRAF (0.54) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5354346 | 0.70 | BRAF (0.52) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL14839424 | 0.70 | BRAF (1.00) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL1647080 | 0.70 | MAPK14 (0.68) | BRAFSRCKDRMAPK14CSNK1D | |
| SCHEMBL5356381 | 0.70 | KDR (0.52) | BRAFSRCKDRMAPK14CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | BRAF 2044/4885SRC 3264/4885KDR 534/4885 |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | BRAF 2413/4885SRC 3785/4885KDR 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.