Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.71 |
| ▸ | GRM5 | P41594 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070291 | 0.93 | MAPT (0.64) | MAPTSMN1; SMN2NTRK1GRM5LMNA | |
| SCHEMBL14133182 | 0.87 | MAPT (0.79) | MAPTSMN1; SMN2GRM5LMNAALDH1A1 | |
| SCHEMBL14132521 | 0.86 | MAPT (0.77) | MAPTSMN1; SMN2GRM5LMNAALDH1A1 | |
| SCHEMBL18925827 | 0.83 | NTRK1 (1.00) | NTRK1GRM5LMNA | |
| SCHEMBL15070275 | 0.81 | SMN1; SMN2 (0.52) | MAPTSMN1; SMN2NTRK1GRM5LMNA | |
| SCHEMBL16586620 | 0.81 | NTRK1 (1.00) | MAPTSMN1; SMN2NTRK1GRM5LMNA | |
| SCHEMBL17111094 | 0.81 | NTRK1 (0.82) | NTRK1GRM5LMNAPOLB | |
| SCHEMBL31324307 | 0.78 | MAPT (0.88) | MAPTSMN1; SMN2GRM5LMNAALDH1A1 | |
| SCHEMBL5924123 | 0.78 | GRM5 (1.00) | MAPTNTRK1GRM5LMNAALDH1A1 | |
| SCHEMBL31324301 | 0.78 | GRM5 (0.59) | MAPTSMN1; SMN2NTRK1GRM5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | MAPT 4368/4885SMN1; SMN2 3990/4885NTRK1 4482/4885 |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | MAPT 4398/4885SMN1; SMN2 3783/4885NTRK1 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.