Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 16/20 | 0.75 |
| ▸ | PAK3 | O75914 | 14/20 | 0.75 |
| ▸ | PAK2 | Q13177 | 14/20 | 0.75 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071039 | 0.86 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15071040 | 0.86 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15071205 | 0.84 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15071033 | 0.84 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15071035 | 0.84 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15071190 | 0.83 | PAK1 (0.75) | PAK1PAK3PAK2PAK4IGF1R | |
| SCHEMBL15071195 | 0.83 | PAK1 (0.75) | PAK1PAK3PAK2PAK4IGF1R | |
| SCHEMBL15059329 | 0.83 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15060160 | 0.83 | PAK1 (1.00) | PAK1PAK3PAK2PAK4NTRK1 | |
| SCHEMBL15209288 | 0.83 | PAK1 (0.72) | PAK1PAK3PAK2IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013092940-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |