Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.43 |
| ▸ | JAK3 | P52333 | 12/20 | 0.43 |
| ▸ | JAK1 | P23458 | 11/20 | 0.43 |
| ▸ | STAT3 | P40763 | 9/20 | 0.43 |
| ▸ | TYK2 | P29597 | 9/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15059532 | 0.84 | JAK2 (0.45) | JAK2JAK3JAK1STAT3TYK2 | |
| SCHEMBL15059530 | 0.84 | JAK2 (0.45) | JAK2JAK3JAK1STAT3TYK2 | |
| SCHEMBL2582400 | 0.74 | JAK3 (0.43) | JAK2JAK3JAK1STAT3TYK2 | |
| SCHEMBL16337534 | 0.71 | JAK3 (0.45) | JAK2JAK3JAK1STAT3TYK2 | |
| SCHEMBL16336319 | 0.71 | JAK3 (0.45) | JAK2JAK3JAK1STAT3TYK2 | |
| SCHEMBL15059211 | 0.71 | JAK3 (0.43) | JAK2JAK3JAK1AURKBBTK | |
| SCHEMBL15059213 | 0.71 | JAK3 (0.43) | JAK2JAK3JAK1AURKBBTK | |
| SCHEMBL15058843 | 0.71 | JAK3 (0.45) | JAK2JAK3JAK1TBK1BTK | |
| SCHEMBL15058844 | 0.71 | JAK3 (0.45) | JAK2JAK3JAK1TBK1BTK | |
| SCHEMBL15060038 | 0.70 | JAK1 (0.45) | JAK2JAK3JAK1STAT3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013092854-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |