Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 17/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 11/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 10/20 | 0.55 |
| ▸ | PSMB8 | P28062 | 9/20 | 0.55 |
| ▸ | PSMB9 | P28065 | 9/20 | 0.55 |
| ▸ | PSMB6 | P28072 | 9/20 | 0.55 |
| ▸ | PSMB10 | P40306 | 9/20 | 0.55 |
| ▸ | LONP1 | P36776 | 8/20 | 0.55 |
| ▸ | PSMB11 | A5LHX3 | 8/20 | 0.55 |
| ▸ | PSMA7 | O14818 | 8/20 | 0.55 |
| ▸ | PSMA1 | P25786 | 8/20 | 0.55 |
| ▸ | PSMA2 | P25787 | 8/20 | 0.55 |
| ▸ | PSMA3 | P25788 | 8/20 | 0.55 |
| ▸ | PSMA4 | P25789 | 8/20 | 0.55 |
| ▸ | PSMA5 | P28066 | 8/20 | 0.55 |
| ▸ | PSMB4 | P28070 | 8/20 | 0.55 |
| ▸ | PSMB3 | P49720 | 8/20 | 0.55 |
| ▸ | PSMA6 | P60900 | 8/20 | 0.55 |
| ▸ | PSMA8 | Q8TAA3 | 8/20 | 0.55 |
| ▸ | PSMB7 | Q99436 | 8/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20408480 | 1.00 | PSMB5 (0.59) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL18316250 | 0.94 | PSMB5 (0.60) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194201 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21210534 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194044 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194105 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194157 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194079 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194058 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 | |
| SCHEMBL21194160 | 0.94 | PSMB5 (0.57) | PSMB5PSMB1PSMB2PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265111-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-08-24 | — | — | US | disclosed |
| US-11325942-B2 | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis | BEIJING ARTIVILA BIOPHARMA CO. LTD. (CN) | 2022-05-10 | — | — | US | disclosed |
| US-20220009948-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-01-13 | — | — | US | disclosed |
| US-20210198289-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-07-01 | — | — | US | disclosed |
| US-20210155658-A1 | CHIRAL SPECIFIC BORON-CONTAINING COMPOUNDS AND THEIR USE IN TREATING CANCER OR AMYLOIDOSIS | ARTIVILA (SHENZHEN) INNOVATION CENTER, LTD. (CN) | 2021-05-27 | — | — | US | disclosed |
| US-20200392164-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-12-17 | — | — | US | disclosed |
| US-20200181176-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-06-11 | — | — | US | disclosed |
| US-10604538-B2 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENIUM PHARMACEUTICALS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| EP-3536693-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263839-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-08-29 | — | — | US | disclosed |
| US-20160368945-A1 | CHIRAL SPECIFIC BORON-CONTAINING COMPOUNDS AND THEIR USE IN TREATING CANCER OR AMYLOIDOSIS | ARTIVILA (SHENZHEN) INNOVATION CENTER, LTD. (CN) | 2016-12-22 | — | — | US | disclosed |
| US-20160031913-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-02-04 | — | — | US | disclosed |
| US-9175017-B2 | Boronate ester compounds and pharmaceutical compositions thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-11-03 | — | — | US | disclosed |
| US-9175018-B2 | Boronate ester compounds and pharmaceutical compositions thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-11-03 | — | — | US | disclosed |
| US-20150307523-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-29 | — | — | US | disclosed |
| US-20140349966-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARM INC (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140343314-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-11-20 | — | — | US | disclosed |
| US-8859504-B2 | Boronate ester compounds and pharmaceutical compositions thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20140018301-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-20130165390-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018301-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20140349966-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20160368945-A1 | CHIRAL SPECIFIC BORON-CONTAINING COMPOUNDS AND THEIR USE IN TREATING CANCER OR AMYLOIDOSIS | TBCA, BCL3, BCL6 | PSMB5 1303/4885PSMB1 1087/4885PSMB2 1445/4885 |
| US-20210198289-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20210155658-A1 | CHIRAL SPECIFIC BORON-CONTAINING COMPOUNDS AND THEIR USE IN TREATING CANCER OR AMYLOIDOSIS | TBCA, BCL3, BCL6 | PSMB5 1303/4885PSMB1 1087/4885PSMB2 1445/4885 |
| US-20150307523-A9 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20160031913-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20190263839-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20230265111-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-10604538-B2 | Boronate ester compounds and pharmaceutical compositions thereof | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20220009948-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20140343314-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-11325942-B2 | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis | TBCA, BCL3, BCL6 | PSMB5 1303/4885PSMB1 1087/4885PSMB2 1445/4885 |
| US-20130165390-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20200392164-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
| US-20200181176-A1 | BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PSMB5, PSMB11, PSMB3 | PSMB5 1/4885PSMB1 13/4885PSMB2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.