Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.64 |
| ▸ | KDM1A | O60341 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507551 | 1.00 | ENPP1 (0.64) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL163465 | 0.94 | ENPP1 (0.71) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL29478510 | 0.94 | ENPP1 (0.71) | ENPP1KDM1AKDRFLT1EGFR | |
| Hydrochloric Acid SCHEMBL8307436 | 0.93 | ENPP1 (0.69) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL1507564 | 0.91 | ENPP1 (0.66) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL662795 | 0.90 | ENPP1 (0.79) | ENPP1KDRFLT1EGFRFGFR1 | |
| SCHEMBL1013021 | 0.90 | ENPP1 (0.79) | ENPP1KDRFLT1EGFRFGFR1 | |
| SCHEMBL30053845 | 0.90 | ENPP1 (0.79) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL1010156 | 0.90 | ENPP1 (0.79) | ENPP1KDM1AKDRFLT1EGFR | |
| SCHEMBL1011724 | 0.90 | ENPP1 (0.79) | ENPP1KDM1AKDRFLT1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-2295415-A1 | Quinazoline derivatives | OSI Pharmaceuticals, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
| EP-2163546-A1 | Quinazoline derivatives | Pfizer Products Incorporated (US) | 2010-03-17 | — | — | EP | disclosed |
| US-RE41065-E1 | Alkynl and azido-substituted 4-anilinoquinazolines | PFIZER, INC. (US) | 2009-12-29 | — | — | US | disclosed |
| EP-1110953-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2009-10-28 | — | — | EP | disclosed |
| EP-0817775-B1 | QUINAZOLINE DERIVATIVES | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1110953-A1 | Quinazoline derivatives | PFIZER INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| US-5747498-A | Alkynyl and azido-substituted 4-anilinoquinazolines | PFIZER INC. (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0817775-A1 | QUINAZOLINE DERIVATIVES | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030347-A1 | QUINAZOLINE DERIVATIVES | PFIZER INC. (US) | 1996-10-03 | — | — | WO | disclosed |