Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.65 |
| ▸ | GAK | O14976 | 4/20 | 0.65 |
| ▸ | FBP1 | P09467 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.60 |
| ▸ | BUB1 | O43683 | 3/20 | 0.60 |
| ▸ | STK10 | O94804 | 3/20 | 0.60 |
| ▸ | MAP3K1 | Q13233 | 3/20 | 0.60 |
| ▸ | ABL1 | P00519 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.60 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.60 |
| ▸ | ILK | Q13418 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507525 | 0.92 | EGFR (0.71) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507658 | 0.92 | EGFR (0.64) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507726 | 0.91 | EGFR (0.64) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507674 | 0.91 | EGFR (0.66) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507707 | 0.90 | EGFR (0.62) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507671 | 0.88 | EGFR (0.60) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507656 | 0.88 | EGFR (0.59) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507458 | 0.87 | EGFR (0.63) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507555 | 0.86 | EGFR (0.61) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1507690 | 0.82 | EGFR (0.83) | EGFRGAKFBP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-2295415-A1 | Quinazoline derivatives | OSI Pharmaceuticals, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
| EP-2163546-A1 | Quinazoline derivatives | Pfizer Products Incorporated (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-0817775-B1 | QUINAZOLINE DERIVATIVES | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1110953-A1 | Quinazoline derivatives | PFIZER INC. (US) | 2001-06-27 | — | — | EP | disclosed |