Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.66 |
| ▸ | JAK3 | P52333 | 10/20 | 0.66 |
| ▸ | JAK2 | O60674 | 9/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234625 | 1.00 | JAK1 (0.66) | JAK1JAK3JAK2 | |
| SCHEMBL15077702 | 1.00 | JAK1 (0.66) | JAK1JAK3JAK2 | |
| SCHEMBL16199578 | 1.00 | JAK1 (0.66) | JAK1JAK3JAK2 | |
| SCHEMBL15077581 | 1.00 | JAK1 (0.66) | JAK1JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL18493482 | 0.99 | JAK1 (0.65) | JAK1JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL16192278 | 0.99 | JAK1 (0.65) | JAK1JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL16192276 | 0.99 | JAK1 (0.65) | JAK1JAK3JAK2 | |
| SCHEMBL15077726 | 0.93 | JAK1 (0.62) | JAK1JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL18493460 | 0.92 | JAK1 (0.61) | JAK1JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL16192313 | 0.92 | JAK1 (0.61) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| WO-2013091539-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | 江苏恒瑞医药股份有限公司 (CN) | 2013-06-27 | — | — | WO | disclosed |