Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.70 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.67 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.67 |
| ▸ | STK17B | O94768 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15078665 | 0.96 | EGFR (0.71) | EGFRKDREPHB4CITGAK | |
| SCHEMBL15879068 | 0.96 | EGFR (0.71) | EGFRKDREPHB4CITGAK | |
| SCHEMBL14971145 | 0.89 | EGFR (0.69) | EGFRKDREPHB4CITGAK | |
| SCHEMBL15946891 | 0.85 | EGFR (0.75) | EGFRKDREPHB4CITGAK | |
| SCHEMBL15879404 | 0.85 | EGFR (0.70) | EGFRKDREPHB4ERBB2FLT4 | |
| SCHEMBL15879405 | 0.85 | EGFR (0.70) | EGFRKDREPHB4ERBB2FLT4 | |
| SCHEMBL6994537 | 0.85 | EGFR (0.70) | EGFRKDREPHB4CITGAK | |
| SCHEMBL15938591 | 0.84 | EGFR (0.75) | EGFRKDREPHB4CITGAK | |
| SCHEMBL14971247 | 0.83 | EGFR (0.81) | EGFRKDREPHB4CITGAK | |
| SCHEMBL22754700 | 0.83 | EGFR (0.81) | EGFRKDREPHB4CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546179-B2 | Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof | Qian, Wei (CN) | 2017-01-17 | — | — | US | disclosed |
| US-9546179-B2 | Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof | Qian, Wei (CN) | 2017-01-17 | — | — | US | disclosed |
| US-20140206664-A1 | Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof | QIAN WEI (CN) | 2014-07-24 | — | — | US | disclosed |
| US-20140206664-A1 | Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof | QIAN WEI (CN) | 2014-07-24 | — | — | US | disclosed |
| WO-2013091507-A1 | HETEROCYCLE AMIDO ALKYLOXY SUBSTITUTED QUINAZOLINE DERIVATIVE AND USE THEREOF | QIAN WEI (CN) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206664-A1 | Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof | EGFR, ERBB2, ERBB4 | EGFR 1/4885KDR 96/4885EPHB4 1564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.