Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.74 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.56 |
| ▸ | MUSK | O15146 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | PAK3 | O75914 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15079475 | 0.93 | FLT3 (0.76) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL17706310 | 0.93 | FLT3 (0.76) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL15079462 | 0.93 | FLT3 (0.75) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL16222278 | 0.90 | FLT3 (0.84) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL15079476 | 0.87 | FLT3 (0.79) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL15079650 | 0.87 | FLT3 (0.79) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL15079665 | 0.85 | FLT3 (1.00) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL16222281 | 0.84 | FLT3 (0.87) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL16222279 | 0.84 | FLT3 (0.87) | FLT3BMPR1BMUSKEPHB6MAP3K7 | |
| SCHEMBL15079643 | 0.84 | FLT3 (0.78) | FLT3BMPR1BMUSKEPHB6MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763998-B1 | TRI-HETEROCYCLIC DERIVATIVES, PREPARATION PROCESS AND USES THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2016-04-27 | — | — | EP | disclosed |
| WO-2013091502-A1 | TRI-HETEROCYCLIC DERIVATIVES, PREPARATION PROCESS AND USES THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD. (CN) | 2013-06-27 | — | — | WO | disclosed |