Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | TEK | Q02763 | 10/20 | 0.55 |
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264135 | 0.91 | KDR (0.54) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1266635 | 0.85 | KDR (0.57) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1263829 | 0.84 | KDR (0.55) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1263934 | 0.78 | KDR (0.64) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264109 | 0.77 | KDR (0.83) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264214 | 0.76 | TEK (0.75) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264043 | 0.76 | TEK (0.73) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1263726 | 0.75 | TEK (0.79) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264844 | 0.75 | TEK (0.60) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264952 | 0.74 | TEK (0.84) | KDRTEKBRAFLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476434-B2 | Protein kinase modulators and method of use | AMGEN INC. (US) | 2013-07-02 | — | — | US | disclosed |