Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AMD1 | P17707 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12226016 | 1.00 | RXFP1 (0.35) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL15080708 | 0.88 | ADORA1 (0.45) | ADORA1 | |
| SCHEMBL12226021 | 0.88 | ADORA1 (0.45) | ADORA1 | |
| SCHEMBL12226013 | 0.86 | RXFP1 (0.35) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL15080702 | 0.86 | RXFP1 (0.35) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL15426677 | 0.85 | ADORA1 (0.48) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL12226014 | 0.79 | ADORA1 (0.36) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL15080706 | 0.79 | ADORA1 (0.36) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL15080710 | 0.78 | PI4KA (0.47) | ADORA1ADORA2BADORA2API4KAPI4K2B | |
| SCHEMBL12226020 | 0.78 | PI4KA (0.47) | ADORA1ADORA2BADORA2API4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476247-B2 | Method of reducing intraocular pressure in humans | INOTEK PHARMACEUTICALS CORPORATION (US) | 2013-07-02 | — | — | US | disclosed |