Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835855 | 0.83 | GSK3B (0.74) | GSK3BGSK3AFGFR1CCNT1HRH4 | |
| SCHEMBL8131726 | 0.82 | GSK3B (0.64) | GSK3BGSK3ALMNACCNT1 | |
| SCHEMBL12835876 | 0.81 | GSK3B (0.53) | GSK3BGSK3AALDH1A1 | |
| SCHEMBL8143251 | 0.78 | GSK3B (0.45) | GSK3BGSK3AKDM4EALDH1A1ALPL | |
| SCHEMBL1514117 | 0.78 | POLB (0.43) | GSK3BLMNAKDM4EALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL1514015 | 0.76 | GSK3B (0.45) | GSK3BGSK3AKDM4EALDH1A1 | |
| SCHEMBL8145934 | 0.75 | GSK3B (0.69) | GSK3BGSK3A | |
| SCHEMBL8135071 | 0.74 | GSK3B (0.73) | GSK3BGSK3ACCNT1 | |
| SCHEMBL12835842 | 0.74 | GSK3B (0.72) | GSK3BGSK3ALMNACCNT1KDM4E | |
| Hydrochloric Acid SCHEMBL1514127 | 0.73 | GSK3B (0.71) | GSK3BGSK3AFGFR1LMNACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476267-B2 | Imidazo-, pyrazolopyrazines and imidazotriazines and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-02 | — | — | US | disclosed |