Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 14/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | WEE1 | P30291 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674341 | 0.85 | MAPKAPK5 (1.00) | MAPKAPK5FYNWEE1EGFR | |
| SCHEMBL27254182 | 0.84 | MAPKAPK5 (0.70) | MAPKAPK5FYNEGFR | |
| SCHEMBL1674404 | 0.84 | MAPKAPK5 (0.70) | MAPKAPK5FYNWEE1EGFR | |
| SCHEMBL1674026 | 0.84 | MAPKAPK5 (0.70) | MAPKAPK5FYNWEE1EGFR | |
| SCHEMBL1674234 | 0.83 | MAPKAPK5 (0.66) | MAPKAPK5FYN | |
| SCHEMBL5574912 | 0.82 | MAPKAPK5 (0.76) | MAPKAPK5FYNWEE1AURKA | |
| SCHEMBL14387680 | 0.82 | MAPKAPK5 (0.69) | MAPKAPK5FYNWEE1 | |
| SCHEMBL4392693 | 0.81 | MAPKAPK5 (0.68) | MAPKAPK5FYN | |
| SCHEMBL2071019 | 0.81 | MAPKAPK5 (0.80) | MAPKAPK5FYNAURKA | |
| SCHEMBL2070836 | 0.80 | MAPKAPK5 (0.81) | MAPKAPK5FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027124-B1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-03 | — | — | EP | disclosed |