Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357076 | 0.85 | TYK2 (0.40) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL13641453 | 0.78 | TYK2 (0.53) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL3315693 | 0.77 | TYK2 (0.55) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL12013157 | 0.75 | TYK2 (0.53) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL3313699 | 0.74 | TYK2 (0.55) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL2309382 | 0.74 | TYK2 (0.56) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL2309014 | 0.74 | TYK2 (0.51) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL3313575 | 0.73 | TYK2 (0.58) | TYK2STAT3CSNK2A2CSNK2A1 | |
| SCHEMBL2356721 | 0.72 | TYK2 (0.54) | TYK2STAT3PDE4DCSNK2A2CSNK2A1 | |
| SCHEMBL3312361 | 0.72 | TYK2 (0.41) | TYK2STAT3NR2E1CSNK2A2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350081-B1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-07-03 | — | — | EP | disclosed |