Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 1.00 |
| ▸ | BRAF | P15056 | 19/20 | 0.73 |
| ▸ | EGFR | P00533 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22279526 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL16379948 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL30584457 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL15085291 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL16380189 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL18922180 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL17800204 | 1.00 | RAF1 (1.00) | RAF1BRAFEGFR | |
| SCHEMBL15085420 | 0.92 | RAF1 (0.84) | RAF1BRAFEGFR | |
| SCHEMBL18922271 | 0.92 | RAF1 (0.84) | RAF1BRAFEGFR | |
| SCHEMBL18922160 | 0.92 | RAF1 (0.84) | RAF1BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013097224-A1 | FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |