Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15085519 | 0.92 | BTK (0.68) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL15085513 | 0.91 | BTK (0.66) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL611781 | 0.87 | BTK (0.64) | BTK | |
| SCHEMBL611350 | 0.84 | BTK (0.69) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL15085521 | 0.84 | BTK (0.63) | BTK | |
| SCHEMBL610713 | 0.83 | BTK (0.67) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL611444 | 0.80 | BTK (0.69) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL610078 | 0.79 | BTK (0.70) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL611686 | 0.79 | BTK (0.74) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL611685 | 0.79 | BTK (0.74) | BTKKCNH2YES1FGRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481540-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2013-07-09 | — | — | US | claimed |