Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806059 | 0.89 | HRH4 (0.52) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL15085656 | 0.87 | HRH4 (0.42) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2804972 | 0.86 | HRH4 (0.49) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2804622 | 0.86 | HRH4 (0.47) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2806878 | 0.85 | HRH4 (0.48) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL13125614 | 0.83 | HRH4 (0.47) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2807456 | 0.82 | HRH4 (0.55) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2805838 | 0.82 | HRH4 (0.52) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2802996 | 0.82 | HRH4 (0.48) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2806440 | 0.81 | HRH4 (0.51) | HRH4HTR3AHTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481732-B2 | Substituted heterocyclic compounds | INCYTE CORPORATION (US) | 2013-07-09 | — | — | US | claimed |
| US-8481732-B2 | Substituted heterocyclic compounds | INCYTE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |