Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 10/20 | 0.40 |
| ▸ | BTK | Q06187 | 9/20 | 0.40 |
| ▸ | LCK | P06239 | 6/20 | 0.40 |
| ▸ | ITK | Q08881 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | YES1 | P07947 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | FGR | P09769 | 2/20 | 0.39 |
| ▸ | FRK | P42685 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15087011 | 0.92 | SRC (0.44) | SRCEGFRBTKLCKITK | |
| SCHEMBL18380717 | 0.91 | EGFR (0.47) | SRCEGFRBTKLCKITK | |
| SCHEMBL14706398 | 0.89 | SRC (0.51) | SRCEGFRBTKLCKITK | |
| SCHEMBL14693535 | 0.87 | SRC (0.50) | SRCEGFRBTKLCKITK | |
| SCHEMBL14693536 | 0.87 | SRC (0.50) | SRCEGFRBTKLCKITK | |
| SCHEMBL18380714 | 0.87 | SRC (0.45) | SRCEGFRBTKLCKITK | |
| SCHEMBL18380709 | 0.87 | SRC (0.45) | SRCEGFRBTKLCKITK | |
| SCHEMBL14706386 | 0.86 | SRC (0.50) | SRCEGFRBTKLCKITK | |
| SCHEMBL18380715 | 0.84 | SRC (0.44) | SRCEGFRBTKLCKITK | |
| SCHEMBL15087016 | 0.83 | SRC (0.44) | SRCEGFRBTKLCKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| WO-2013102059-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE AND PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |