Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | GGT1 | P19440 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836700 | 1.00 | TLR2 (0.53) | TLR2POLBMMEGGT1HDAC3 | |
| SCHEMBL1508827 | 1.00 | TLR2 (0.53) | TLR2POLBMMEGGT1HDAC3 | |
| SCHEMBL25380272 | 0.90 | TLR2 (0.61) | TLR2POLBMMEGGT1EPHX2 | |
| Hydrochloric Acid SCHEMBL3229765 | 0.87 | TLR2 (0.65) | TLR2POLBEPHX2 | |
| SCHEMBL30426128 | 0.87 | TLR2 (0.69) | TLR2POLBEPHX2 | |
| SCHEMBL27656566 | 0.87 | TLR2 (0.51) | TLR2POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL7396775 | 0.86 | POLB (0.62) | TLR2POLBMMESIGMAR1GAA | |
| SCHEMBL14793543 | 0.86 | POLB (0.62) | TLR2POLBMMESIGMAR1GAA | |
| SCHEMBL14793559 | 0.86 | POLB (0.62) | TLR2POLBMMESIGMAR1GAA | |
| SCHEMBL18939228 | 0.85 | MAPT (0.56) | TLR2POLBGAAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380892-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-10-26 | — | — | EP | disclosed |
| EP-2298778-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING 4,7-DIAZASPIROÝ2.5¨OCTANE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-03-23 | — | — | EP | disclosed |