Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.46 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973854 | 0.90 | MAP2K1 (0.67) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL3980531 | 0.86 | MAP2K1 (0.57) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL3973013 | 0.84 | MAP2K1 (0.53) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL15088120 | 0.81 | MAP2K1 (0.45) | MAP2K1MAP2K2NUDT1 | |
| SCHEMBL15088163 | 0.79 | MAP2K1 (0.57) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL3973498 | 0.78 | MAP2K1 (0.69) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL14499791 | 0.78 | MAP2K1 (0.57) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL3973688 | 0.76 | MAP2K1 (0.53) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL13842013 | 0.76 | MAP2K1 (0.65) | MAP2K1MAP2K2CSNK2A2 | |
| SCHEMBL14021277 | 0.75 | MAP2K1 (0.75) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673339-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2013-07-03 | — | — | EP | disclosed |