Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | ROR1 | Q01973 | 6/20 | 0.61 |
| ▸ | ABL1 | P00519 | 12/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15096062 | 0.87 | ROR1 (0.67) | CSF1RROR1ABL1KCNH2FGFR1 | |
| SCHEMBL589881 | 0.87 | CSF1R (0.67) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL29506341 | 0.87 | CSF1R (0.67) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL12652759 | 0.86 | CSF1R (0.66) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL22243490 | 0.86 | CSF1R (0.66) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL29493472 | 0.86 | CSF1R (0.66) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL22580709 | 0.85 | CSF1R (0.61) | CSF1RROR1ABL1KCNH2FGFR1 | |
| SCHEMBL30010219 | 0.84 | CSF1R (0.72) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL19317721 | 0.81 | ROR1 (0.79) | CSF1RROR1ABL1KCNH2CYP3A4 | |
| SCHEMBL24123162 | 0.80 | ABL1 (0.66) | CSF1RROR1ABL1KCNH2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013101281-A1 | METHODS AND COMPOSITIONS FOR TREATING PARKINSON'S DISEASE | ARIAD PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |