Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14090605 | 0.90 | ABCB1 (0.43) | ABCB1ABCG2DDR2ABL1ALK | |
| SCHEMBL1509498 | 0.89 | ABCG2 (0.48) | CARM1ABCB1ABCG2DDR2 | |
| SCHEMBL14090443 | 0.84 | ABCB1 (0.43) | CARM1ABCB1ABCG2DDR2GSK3B | |
| SCHEMBL12834002 | 0.83 | ABCB1 (0.45) | CARM1ABCB1ABCG2GSK3B | |
| SCHEMBL12833863 | 0.83 | ABCB1 (0.42) | ABCB1ABCG2ABL1ALKGSK3B | |
| SCHEMBL14090225 | 0.83 | HDAC6 (0.56) | CARM1DDR2ABL1ALKEGFR | |
| SCHEMBL16462882 | 0.83 | ABCG2 (0.51) | CARM1ABCB1ABCG2DDR2 | |
| SCHEMBL1509568 | 0.83 | ABCG2 (0.44) | CARM1ABCB1ABCG2 | |
| SCHEMBL14090449 | 0.82 | ABCG2 (0.44) | CARM1ABCB1ABCG2GSK3B | |
| SCHEMBL12833550 | 0.82 | ABCB1 (0.44) | CARM1ABCB1ABCG2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |