Sugi Predict

Sugi Predict / Compounds / SCHEMBL15096639

SCHEMBL15096639

SCHEMBL15096639

CCCCCCCOc1ccc(-c2cnc(-c3ccc(C[C@H](NC(=O)c4ccc(C(C)(C)C)cc4)C(=O)NCCCC(=O)O)cc3)nc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLG P00747 2/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ GCGR P47871 2/20 0.48
▸ KLKB1 P03952 2/20 0.47
▸ PPARG P37231 3/20 0.44
▸ PPARA Q07869 1/20 0.44
▸ PRSS1 P07477 1/20 0.43
▸ PRSS2 P07478 1/20 0.43
▸ PRSS3 P35030 1/20 0.43
▸ ADCY6 O43306 1/20 0.43
▸ ADCY3 O60266 1/20 0.43
▸ ADCY9 O60503 1/20 0.43
▸ ADCY5 O95622 1/20 0.43
▸ ADCY8 P40145 1/20 0.43
▸ ADCY7 P51828 1/20 0.43
▸ ADCY2 Q08462 1/20 0.43
▸ ADCY1 Q08828 1/20 0.43
▸ ADCY4 Q8NFM4 1/20 0.43
▸ FOLH1 Q04609 2/20 0.43
▸ ITGB1 P05556 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16305825 0.96 GCGR (0.52) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL15019651 0.96 GCGR (0.52) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL16305921 0.96 GCGR (0.52) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL15019653 0.96 GCGR (0.52) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL16380079 0.96 GCGR (0.52) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL16305819 0.95 GCGR (0.53) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL16306150 0.94 GCGR (0.54) PLGL3MBTL1GCGRKLKB1ADCY6
SCHEMBL15037348 0.92 PLG (0.49) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL15019646 0.92 PLG (0.49) PLGL3MBTL1GCGRKLKB1PPARG
SCHEMBL15019649 0.92 PLG (0.49) PLGL3MBTL1GCGRKLKB1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10259823-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2019-04-16 — — US disclosed
US-10034886-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2018-07-31 — — US disclosed
US-10034886-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2018-07-31 — — US disclosed
US-20170313717-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2017-11-02 — — US disclosed
US-9795613-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-10-24 — — US disclosed
US-9795613-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2017-10-24 — — US disclosed
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-08-11 — — US disclosed
US-20160214993-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2016-07-28 — — US disclosed
WO-2016094729-A1 GLP-1 RECEPTOR MODULATORS CELGENE INTERNATIONAL II SARL (CH) 2016-06-16 — — WO disclosed
US-9187522-B2 GLP-1 receptor modulators RECEPTOS, INC. (US) 2015-11-17 — — US disclosed
US-9187522-B2 GLP-1 receptor modulators RECEPTOS, INC. (US) 2015-11-17 — — US disclosed
US-20150038416-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2015-02-05 — — US disclosed
US-20150038416-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2015-02-05 — — US disclosed
US-20150011527-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2015-01-08 — — US disclosed
WO-2014201172-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2014-12-18 — — WO disclosed
US-8778923-B2 GLP-1 receptor modulators RECEPTOS, INC. (US) 2014-07-15 — — US disclosed
US-8778923-B2 GLP-1 receptor modulators RECEPTOS, INC. (US) 2014-07-15 — — US disclosed
US-20130178420-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2013-07-11 — — US disclosed
US-20130178420-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2013-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160228450-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3184/4885L3MBTL1 771/4885GCGR 4/4885
US-20170313717-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3184/4885L3MBTL1 771/4885GCGR 4/4885
US-20160214993-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3184/4885L3MBTL1 771/4885GCGR 4/4885
US-20130178420-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3214/4885L3MBTL1 728/4885GCGR 4/4885
US-20150038416-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3214/4885L3MBTL1 728/4885GCGR 4/4885
US-10034886-B2 GLP-1 receptor modulators GLP1R, GIPR, GCGR PLG 2930/4885L3MBTL1 579/4885GCGR 3/4885
US-10259823-B2 GLP-1 receptor modulators GLP1R, GIPR, GCGR PLG 2930/4885L3MBTL1 579/4885GCGR 3/4885
US-20150011527-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R PLG 3184/4885L3MBTL1 771/4885GCGR 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback