Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 18/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 17/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757948 | 0.79 | NPC1 (0.45) | SCN5ASCN9A | |
| SCHEMBL14090024 | 0.73 | ABCG2 (0.40) | ABCB1ABCG2CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL14090004 | 0.73 | IKBKB (0.42) | ABCB1ABCG2CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL14091169 | 0.72 | EGFR (0.44) | ABCB1ABCG2CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL14091172 | 0.71 | FLT3 (0.39) | ABCB1ABCG2 | |
| SCHEMBL14090162 | 0.71 | IKBKB (0.40) | ABCB1ABCG2CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL14090038 | 0.70 | CSF1R (0.38) | ABCB1ABCG2CYP1A2CYP2C8CYP2D6 | |
| SCHEMBL14090045 | 0.70 | FLT3 (0.40) | ABCB1ABCG2 | |
| SCHEMBL14090047 | 0.69 | CSF1R (0.40) | ABCB1ABCG2 | |
| SCHEMBL14089982 | 0.69 | MAPT (0.42) | SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |