Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.65 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449644 | 0.89 | HRH3 (0.56) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL13052 | 0.89 | HRH3 (0.56) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL12449633 | 0.89 | HRH3 (0.56) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL9374424 | 0.88 | HRH3 (0.53) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL17277607 | 0.86 | KDM4E (0.55) | HRH3KDM4EALDH1A1 | |
| SCHEMBL12449641 | 0.86 | KDM4E (0.54) | HRH3MAOBKDM4E | |
| SCHEMBL13102 | 0.86 | KDM4E (0.54) | HRH3MAOBKDM4E | |
| SCHEMBL26787071 | 0.84 | HRH3 (0.55) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL22861342 | 0.84 | HRH3 (0.52) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL25840368 | 0.84 | HRH3 (0.52) | HRH3HRH2HRH1MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486947-B2 | Treatment of Parkinson's disease, obstructive sleep apnea, dementia with Lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3-receptor ligands | BIOPROJET (FR) | 2013-07-16 | — | — | US | claimed |