SCHEMBL15127366

SCHEMBL15127366

CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@@H](C(=O)N[C@H](Cc2ccc3ccccc3c2)C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 13/20 0.56
▸ MC1R Q01726 4/20 0.56
▸ FURIN P09958 2/20 0.55
▸ TUBB4A P04350 2/20 0.48
▸ TUBB P07437 2/20 0.48
▸ TUBA3C P0DPH7 2/20 0.48
▸ TUBA1B P68363 2/20 0.48
▸ TUBA4A P68366 2/20 0.48
▸ TUBB4B P68371 2/20 0.48
▸ TUBB3 Q13509 2/20 0.48
▸ TUBB2A Q13885 2/20 0.48
▸ TUBB8 Q3ZCM7 2/20 0.48
▸ TUBA3E Q6PEY2 2/20 0.48
▸ TUBA1A Q71U36 2/20 0.48
▸ TUBA1C Q9BQE3 2/20 0.48
▸ TUBB6 Q9BUF5 2/20 0.48
▸ TUBB2B Q9BVA1 2/20 0.48
▸ TUBB1 Q9H4B7 2/20 0.48
▸ MDM2 Q00987 1/20 0.45
▸ FCGRT P55899 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12657943 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL22606119 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL21392451 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL12657865 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL22606151 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL21392452 1.00 MC4R (0.56) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL12092503 0.96 MC4R (0.52) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL12092510 0.96 MC4R (0.52) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL21392446 0.94 MC4R (0.49) MC4RMC1RFURINTUBB4ATUBB
SCHEMBL12657866 0.93 MC4R (0.60) MC4RMC1RFURINTUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine PALATIN TECHNOLOGIES, INC. (US) 2020-07-14 — — US disclosed
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides PALATIN TECHNOLOGIES, INC. (US) 2018-07-10 — — US disclosed
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine PALATIN TECHNOLOGIES INC (US) 2018-05-31 — — US disclosed
US-20170008931-A1 Melanocortin-1 Receptor-Specific Cyclic Hexapeptides PALATIN TECHNOLOGIES INC (US) 2017-01-12 — — US disclosed
US-9447148-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2016-09-20 — — US disclosed
US-20150038434-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides PALATIN TECHNOLOGIES INC (US) 2015-02-05 — — US disclosed
US-8877890-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2014-11-04 — — US disclosed
US-20130296256-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides PALATIN TECHNOLOGIES, INC. (US) 2013-11-07 — — US disclosed
US-8492517-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2013-07-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine MC1R, MC3R, MC4R MC4R 3/4885MC1R 1/4885FURIN 1061/4885
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 867/4885
US-20150038434-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 1147/4885
US-20170008931-A1 Melanocortin-1 Receptor-Specific Cyclic Hexapeptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 867/4885
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine MC1R, MC3R, MC4R MC4R 3/4885MC1R 1/4885FURIN 1061/4885
US-20130296256-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 1147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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