Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | NRAS | P01111 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15193133 | 1.00 | IRAK4 (0.46) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL2051378 | 0.87 | FLT3 (0.49) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL1996301 | 0.87 | FLT3 (0.49) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL1994861 | 0.86 | FLT3 (0.51) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL1994864 | 0.86 | FLT3 (0.51) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL12616166 | 0.85 | IRAK4 (0.54) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL1995527 | 0.85 | IRAK4 (0.54) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL15193129 | 0.84 | NRAS (0.50) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL15193127 | 0.84 | NRAS (0.50) | IRAK4FLT3CDK7CCNHIRAK1 | |
| SCHEMBL2054237 | 0.84 | FLT3 (0.49) | IRAK4FLT3CDK7CCNHIRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130216498-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2013-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130216498-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK2, JAK3 | IRAK4 12/4885FLT3 21/4885CDK7 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.