Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.84 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.79 |
| ▸ | TNKS | O95271 | 1/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.79 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.79 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.79 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.79 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.79 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.79 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.79 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.79 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.79 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.79 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.79 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.79 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.79 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9280839 | 0.97 | PARP1 (0.83) | PARP1PARP3TNKSADORA1CDK6 | |
| SCHEMBL22852727 | 0.91 | PARP1 (0.98) | PARP1PARP3TNKSADORA1CDK6 | |
| SCHEMBL30293115 | 0.90 | PARP1 (0.89) | PARP1PARP3 | |
| SCHEMBL9285979 | 0.89 | PARP1 (0.86) | PARP1PARP3 | |
| Olaparib SCHEMBL426568 | 0.89 | PARP1 (1.00) | PARP1PARP3TNKSADORA1CDK6 | |
| Olaparib SCHEMBL29352148 | 0.89 | PARP1 (1.00) | PARP1PARP3TNKSADORA1CDK6 | |
| Olaparib SCHEMBL29392087 | 0.89 | PARP1 (1.00) | PARP1PARP3TNKSADORA1CDK6 | |
| SCHEMBL19569971 | 0.88 | PARP1 (0.90) | PARP1PARP3TNKSADORA1CDK6 | |
| SCHEMBL30331782 | 0.87 | PARP1 (0.84) | PARP1PARP3 | |
| SCHEMBL19914129 | 0.87 | PARP1 (0.84) | PARP1PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646428-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2016-06-01 | — | — | EP | disclosed |
| US-8999985-B2 | Substituted phthalazin-1(2H)-ones, preparation processes and medical uses thereof | SHANGHAI DE NOVO PHARMATECH CO LTD. (CN) | 2015-04-07 | — | — | US | disclosed |
| CN-103237799-B | Heterocyclic derivates, preparation processes and medical uses thereof | SHANGHAI DE NOVO PHARMATECH CO LTD | 2014-08-20 | — | — | CN | disclosed |
| US-20130224107-A1 | HETEROCYCLIC DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD. (CN) | 2013-08-29 | — | — | US | disclosed |
| CN-103237799-A | Heterocyclic derivates, preparation processes and medical uses thereof | SHANGHAI DE NOVO PHARMATECH CO LTD | 2013-08-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130224107-A1 | HETEROCYCLIC DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF | PARP1, PARP3, PARP2 | PARP1 1/4885PARP3 2/4885TNKS 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.